Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4688-91. doi: 10.1016/j.bmcl.2008.07.001. Epub 2008 Jul 4.

Abstract

The CHCl(3)-soluble fraction of 70% EtOH extract of the flower of Kayea assamica completely killed human pancreatic PANC-1 cancer cells preferentially under nutrient-deprived conditions at 1 microg/mL. Bioassay-guided fractionation and isolation afforded two novel compounds, kayeassamins A (1) and B (2). Their structures were elucidated using extensive spectroscopic methods and the modified Mosher method. Each compound showed 100% preferential cytotoxicity (PC(100)) against PANC-1 cells under nutrient-deprived conditions at 1 microM. Furthermore, both compounds inhibited the migration of PANC-1 cells in the wound closure assay.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cell Line, Tumor
  • Clusiaceae / metabolism*
  • Coumarins / isolation & purification*
  • Coumarins / pharmacology
  • Drug Design
  • Drug Screening Assays, Antitumor*
  • Flowers / metabolism
  • Humans
  • Magnetic Resonance Spectroscopy
  • Models, Chemical
  • Monoterpenes / isolation & purification*
  • Monoterpenes / pharmacology
  • Myanmar
  • Pancreatic Neoplasms / drug therapy*
  • Plant Extracts / pharmacology*

Substances

  • Antineoplastic Agents, Phytogenic
  • Coumarins
  • Monoterpenes
  • Plant Extracts
  • kayeassamin A
  • kayeassamin B