Abstract
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studies on the macrocyclization step are reported.
MeSH terms
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Chemistry, Pharmaceutical / methods*
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Combinatorial Chemistry Techniques
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Dimerization
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Dipeptides
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Models, Chemical
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Models, Molecular
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Molecular Conformation
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Molecular Mimicry
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Molecular Structure
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Peptides / chemistry
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Peptides, Cyclic / chemistry*
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Silver / chemistry
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Dipeptides
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Peptides
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Peptides, Cyclic
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Silver