A review of critical factors in the conduct and interpretation of the human repeat insult patch test

Pauline M McNamee; Anne Marie Api; David A Basketter; G Frank Gerberick; Deborah A Gilpin; Barbara M Hall; Ian Jowsey; Michael K Robinson

doi:10.1016/j.yrtph.2007.10.019

A review of critical factors in the conduct and interpretation of the human repeat insult patch test

Regul Toxicol Pharmacol. 2008 Oct;52(1):24-34. doi: 10.1016/j.yrtph.2007.10.019. Epub 2007 Dec 4.

Authors

Pauline M McNamee¹, Anne Marie Api, David A Basketter, G Frank Gerberick, Deborah A Gilpin, Barbara M Hall, Ian Jowsey, Michael K Robinson

Affiliation

¹ The Procter & Gamble Company, Whitehall Lane, Egham, Surrey TW209NW, UK. mcnamee.pm@pg.com

PMID: 18639964
DOI: 10.1016/j.yrtph.2007.10.019

Abstract

This paper reviews key factors that are critical to the conduct and interpretation of Human Repeat Insult Patch Tests (HRIPTs). A methodology for HRIP testing is described and general guidelines for evaluation of responses indicative of induction and elicitation of skin sensitization and skin irritation are detailed. Understanding and applying these key factors is crucial to the design of such studies and reliability of the resulting data when used in the overall risk assessment process.

Publication types

Review

MeSH terms

Animals
Consumer Product Safety
Dermatitis, Allergic Contact / diagnosis*
Dermatitis, Allergic Contact / etiology
Guidelines as Topic
Humans
Patch Tests / methods*
Reproducibility of Results
Risk Assessment / methods