Abstract
An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with sialyl alpha(2-->3) lactose (Neu5Acalpha(2-->3)Galbeta(1-->4)Glcbeta1-->) moieties was accomplished. The results of a preliminary study on biological responses against influenza virus hemagglutinin, using the sialyl lactose clusters showed unique biological activities on the basis of the structure-activity relationship according to the carbosilane scaffolds.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Combinatorial Chemistry Techniques*
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Dendrimers / chemical synthesis*
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Dendrimers / chemistry
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Dendrimers / pharmacology*
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Drug Design*
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Hemagglutination Tests
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Hemagglutinin Glycoproteins, Influenza Virus / metabolism*
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Humans
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Influenza A Virus, H1N1 Subtype / drug effects
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Influenza A Virus, H3N2 Subtype / drug effects
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Lactose / analogs & derivatives*
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Lactose / chemical synthesis*
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Lactose / chemistry
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Lactose / pharmacology*
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Molecular Structure
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Parainfluenza Virus 1, Human / drug effects
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Silanes / chemical synthesis*
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Silanes / chemistry
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Silanes / pharmacology*
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Structure-Activity Relationship
Substances
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Antiviral Agents
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Dendrimers
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Hemagglutinin Glycoproteins, Influenza Virus
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Silanes
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Lactose