Abstract
The sialyl Lewis x tetrasaccharide with a propylamine aglycon was assembled by chemoselective glycosylation from a p-tolyl thioglycosyl donor obtained from an enzymatically synthesized sialodisaccharide. Combining the advantages of highly efficient enzymatic synthesis of sialoside building blocks, and diverse chemical glycosylation, this chemoenzymatic approach is practical for obtaining complex sialosides and their analogues.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Humans
-
Inflammation / physiopathology
-
Models, Molecular
-
Molecular Conformation
-
Neoplasm Metastasis / physiopathology
-
Oligosaccharides / chemical synthesis*
-
Oligosaccharides / chemistry
-
Oligosaccharides / metabolism
-
Selectins / physiology
-
Sialic Acids / chemistry
-
Sialyl Lewis X Antigen
Substances
-
Oligosaccharides
-
Selectins
-
Sialic Acids
-
Sialyl Lewis X Antigen