Bivalent aptamers deliver the punch

Jiehua Zhou; John J Rossi

doi:10.1016/j.chembiol.2008.07.004

Bivalent aptamers deliver the punch

Chem Biol. 2008 Jul 21;15(7):644-5. doi: 10.1016/j.chembiol.2008.07.004.

Authors

Jiehua Zhou¹, John J Rossi

Affiliation

¹ Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.

PMID: 18635000
DOI: 10.1016/j.chembiol.2008.07.004

Abstract

Aptamers, sometimes termed "chemical antibodies," have been engineered into multimerized versions for therapeutic application. The groups of Gilboa and Sullenger now report the development of a bivalent aptamer-molecular device as a receptor agonist that has the same functional properties, but stronger avidity than a corresponding antibody.

MeSH terms

Animals
Antibodies / chemistry*
Aptamers, Nucleotide*
DNA / chemistry
Dimerization
Humans
Ligands
Models, Chemical
Molecular Conformation
Nucleic Acids / chemistry
Protein Engineering / methods*
Receptors, OX40 / chemistry
T-Lymphocytes, Cytotoxic / chemistry

Substances

Antibodies
Aptamers, Nucleotide
Ligands
Nucleic Acids
Receptors, OX40
DNA