Ortho-lithiation of free ferrocenyl alcohols: a new method for the synthesis of planar chiral ferrocene derivatives

Bernhard J Ueberbacher; Herfried Griengl; Hansjörg Weber

doi:10.1039/b807895e

Ortho-lithiation of free ferrocenyl alcohols: a new method for the synthesis of planar chiral ferrocene derivatives

Chem Commun (Camb). 2008 Jul 28:(28):3287-9. doi: 10.1039/b807895e. Epub 2008 Jun 17.

Authors

Bernhard J Ueberbacher¹, Herfried Griengl, Hansjörg Weber

Affiliation

¹ Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 16, 8010 Graz, Austria. Bernhard.ueberbacher@tugraz.at

PMID: 18622446
DOI: 10.1039/b807895e

Abstract

An ortho-metalation method for free ferrocenyl alcohols has been developed, which allows preparation of planar chiral ferrocene derivatives with high yields and diastereoselectivities.

MeSH terms

Alcohols / chemical synthesis*
Ferrous Compounds / chemical synthesis*
Lithium / chemistry*
Metallocenes
Organometallic Compounds / chemistry
Stereoisomerism

Substances

Alcohols
Ferrous Compounds
Metallocenes
Organometallic Compounds
butyllithium
Lithium
ferrocene