Alpha-glucosidase inhibitor from Bergenia ligulata

J Oleo Sci. 2008;57(8):431-5. doi: 10.5650/jos.57.431.

Abstract

Inhibitory compound of alpha-glucosidase activity, (+)-afzelechin (1), was isolated from rhizomes of Bergenia ligulata. The structure was identified by IR, EI-MS, (1)H and (13)C NMR spectroscopy. The ID(50) (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-afzelechin tetraacetate (2), (+)-5,7,4'-trimethoxyafzelechin (3), (+)-tetramethoxyafzelechin (4), and (+)-3-acetyl-5,7,4'-trimethoxyafzelechin (5) as the derivatives of compound 1 were evaluated as well.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzopyrans / chemistry
  • Benzopyrans / pharmacology*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Flavonoids
  • Glycoside Hydrolase Inhibitors*
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / isolation & purification
  • Hypoglycemic Agents / pharmacology*
  • Phenols / chemistry
  • Phenols / pharmacology*
  • Plants, Medicinal / chemistry*
  • Rhizome / chemistry*
  • Spectrum Analysis
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Benzopyrans
  • Enzyme Inhibitors
  • Flavonoids
  • Glycoside Hydrolase Inhibitors
  • Hypoglycemic Agents
  • Phenols
  • afzelechin