Abstract
Inhibitory compound of alpha-glucosidase activity, (+)-afzelechin (1), was isolated from rhizomes of Bergenia ligulata. The structure was identified by IR, EI-MS, (1)H and (13)C NMR spectroscopy. The ID(50) (50% inhibition dose) value of compound 1 was 0.13 mM. To investigate the structure-activity relationship, (+)-afzelechin tetraacetate (2), (+)-5,7,4'-trimethoxyafzelechin (3), (+)-tetramethoxyafzelechin (4), and (+)-3-acetyl-5,7,4'-trimethoxyafzelechin (5) as the derivatives of compound 1 were evaluated as well.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzopyrans / chemistry
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Benzopyrans / pharmacology*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / isolation & purification
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Enzyme Inhibitors / pharmacology*
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Flavonoids
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Glycoside Hydrolase Inhibitors*
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / isolation & purification
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Hypoglycemic Agents / pharmacology*
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Phenols / chemistry
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Phenols / pharmacology*
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Plants, Medicinal / chemistry*
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Rhizome / chemistry*
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Spectrum Analysis
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Benzopyrans
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Enzyme Inhibitors
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Flavonoids
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Glycoside Hydrolase Inhibitors
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Hypoglycemic Agents
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Phenols
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afzelechin