Abstract
Maternal-Effect Dominant Embryonic Arrest ("Medea") factors are selfish nuclear elements that combine maternal-lethal and zygotic-rescue activities to gain a postzygotic survival advantage. We show that Medea(1) activity in Tribolium castaneum is associated with a composite Tc1 transposon inserted just downstream of the neurotransmitter reuptake symporter bloated tubules (blot), whose Drosophila ortholog has both maternal and zygotic functions. The 21.5-kb insertion contains defective copies of elongation initiation factor-3, ATP synthase subunit C, and an RNaseD-related gene, as well as a potentially intact copy of a prokaryotic DUF1703 gene. Sequence comparisons suggest that the current distribution of Medea(1) reflects global emanation after a single transpositional event in recent evolutionary time. The Medea system in Tribolium represents an unusual type of intragenomic conflict and could provide a useful vehicle for driving desirable genes into populations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Chromosome Mapping
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Chromosomes, Artificial, Bacterial / genetics
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Cloning, Molecular
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DNA Transposable Elements / genetics*
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Female
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Gene Dosage
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Genes, Insect*
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Genes, Lethal
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Male
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Molecular Sequence Data
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Mutation
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Phylogeny
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Repetitive Sequences, Nucleic Acid*
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Tribolium / genetics*
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Zygote
Substances
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DNA Transposable Elements
Associated data
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GENBANK/EU597633
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GENBANK/EU597634
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GENBANK/EU597635
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GENBANK/EU597636
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GENBANK/EU597637
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GENBANK/EU597638
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GENBANK/EU597639
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GENBANK/EU597640
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GENBANK/EU597641
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GENBANK/EU597642
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GENBANK/EU597643
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GENBANK/EU597650
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GENBANK/EU597651
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GENBANK/EU597652
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GENBANK/EU597653
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GENBANK/EU597654
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GENBANK/EU597655
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GENBANK/EU597656
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GENBANK/EU597657
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GENBANK/EU597658
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GENBANK/EU597659
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GENBANK/EU597660
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GENBANK/EU597661
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GENBANK/EU597664
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GENBANK/EU597666
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GENBANK/EU597668
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GENBANK/EU597670
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GENBANK/EU597671
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GENBANK/EU597678