Cerebellar development and plasticity is involved in various epigenetic processes that activate specific genes at different time point. The epigenetic influences include humoral influences from endocrine cells of peripheral organs. A number of hormone receptors are expressed in cerebellum, and cerebellar function is greatly influenced by hormonal status. Furthermore, recent studies have shown that some of such substances are produced locally and affect through their specific hormone receptors. The aim of this special issue was to introduce several key features of hormones and their receptors to regulate cerebellar development and plasticity. The contribution covers thyroid/steroid hormone systems including orphan receptors and co-regulators, neurosteroids, and transporters. It also covers environmental signal that may affect cerebellar hormonal environment. Furthermore, several neuropeptides, which are initially found as neuroendocrine hormones but later identified as neurotransmitters that play an important role in cerebellar function, are also covered.