Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus

Fanny Ménard; Caroline Besson; Patricia Rincé; Olivier Lambotte; Thierry Lazure; Danielle Canioni; Olivier Hermine; Pierre Brousset; Antoine Martin; Philippe Gaulard; Martine Raphaël; Claire Larroche

doi:10.1086/590152

Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus

Clin Infect Dis. 2008 Aug 15;47(4):531-4. doi: 10.1086/590152.

Authors

Fanny Ménard¹, Caroline Besson, Patricia Rincé, Olivier Lambotte, Thierry Lazure, Danielle Canioni, Olivier Hermine, Pierre Brousset, Antoine Martin, Philippe Gaulard, Martine Raphaël, Claire Larroche

Affiliation

¹ Université Paris-Sud, F-94270, Paris, France.

PMID: 18611160
DOI: 10.1086/590152

Abstract

The retrospective study of 34 patients with Hodgkin lymphoma-associated hemophagocytic syndrome led us to define this association as a specific disorder. Its characteristics are male predominance (male-to-female sex ratio, 3.3:1), immunodeficiency-like histological features (lymphocyte depletion, 45% of cases; mixed cellularity Hodgkin lymphoma subtype, 40%), and strong association with Epstein-Barr virus (94%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Epstein-Barr Virus Infections / complications*
Epstein-Barr Virus Infections / virology
Female
Herpesvirus 4, Human / isolation & purification*
Hodgkin Disease / complications*
Hodgkin Disease / virology*
Humans
Lymphohistiocytosis, Hemophagocytic / epidemiology
Lymphohistiocytosis, Hemophagocytic / etiology*
Lymphohistiocytosis, Hemophagocytic / pathology
Lymphohistiocytosis, Hemophagocytic / virology*
Male
Middle Aged