Abstract
During intravenous treatment with terlipressin for recurrent gastrointestinal (GI) bleeding, a 50-year-old male with no history of heart disease developed a newly prolonged QT interval and torsade de pointes. Risk factors present for acquired long QT syndrome were mineral dysbalance and a history of alcohol abuse with hepatic impairment. The patient was brought back to a normal sinus rhythm after a single 300-J counter-shock. Terlipressin was discontinued, and the patient's QTc interval subsequently returned to baseline. During 6 weeks of monitoring, arrhythmia did not recur.
MeSH terms
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Adult
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Electric Countershock
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Electrocardiography
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Follow-Up Studies
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Gastrointestinal Hemorrhage / diagnosis
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Gastrointestinal Hemorrhage / drug therapy
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Humans
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Infusions, Intravenous
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Long QT Syndrome / chemically induced*
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Long QT Syndrome / diagnosis
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Long QT Syndrome / therapy
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Lypressin / adverse effects
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Lypressin / analogs & derivatives*
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Lypressin / therapeutic use
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Male
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Risk Assessment
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Severity of Illness Index
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Terlipressin
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Torsades de Pointes / chemically induced*
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Torsades de Pointes / diagnosis
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Torsades de Pointes / therapy
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Treatment Outcome
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Vasoconstrictor Agents / adverse effects*
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Vasoconstrictor Agents / therapeutic use
Substances
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Vasoconstrictor Agents
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Lypressin
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Terlipressin