Abstract
We determined the effects of yolk water-soluble protein (YSP) on bone resorption. YSP potently suppressed osteoclastogenesis from bone marrow-derived precursor cells driven by tumor necrosis factor-alpha (TNF-alpha). YSP (200 microg/ml) abolished the formation of tartarate-resistant acid phosphatase (TRAP)-positive osteoclasts. Furthermore, TNF-alpha induced TRAP activity was greatly inhibited by YSP (100 microg/ml) treatment. Our results suggest that YSP has therapeutic potential for bone-erosive diseases.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acid Phosphatase / metabolism
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Animals
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Bone Resorption / drug therapy
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Bone Resorption / prevention & control*
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Cell Differentiation / drug effects
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Cells, Cultured
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Egg Proteins / pharmacology*
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Egg Proteins / therapeutic use
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Isoenzymes / metabolism
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Male
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Mice
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Osteoclasts / cytology
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Osteoporosis / drug therapy
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Tartrate-Resistant Acid Phosphatase
Substances
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Egg Proteins
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Isoenzymes
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Acid Phosphatase
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Acp5 protein, mouse
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Tartrate-Resistant Acid Phosphatase