Abstract
The objective of this study was to evaluate the immunomodulatory effects of the Paecilomyces sinensis polysaccharides (PtP) on the activity of macrophages and human monocytes. A water-soluble polysaccharide, with estimated molecular weight of 2.04x10(4) Da, was isolated from P. sinensis. The results indicate that PtP can increase the activity of LDH and ACP in AMphi and PMphi of rats and human mononuclear cells, and enhance the pinocytic activity of macrophages and TNF-alpha production by human peripheral blood mononuclear cells (PBMC), suggesting that PtP had potent immunomodulatory properties and could be explored as a novel potential immunostimulants for the food and pharmaceutical purpose.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acid Phosphatase / metabolism
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Animals
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Humans
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Immunologic Factors / isolation & purification*
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Immunologic Factors / pharmacology*
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L-Lactate Dehydrogenase / metabolism
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Macrophages / drug effects*
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Macrophages / enzymology
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Macrophages / immunology*
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Macrophages, Alveolar / drug effects
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Macrophages, Alveolar / enzymology
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Macrophages, Alveolar / immunology
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Macrophages, Peritoneal / drug effects
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Macrophages, Peritoneal / enzymology
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Macrophages, Peritoneal / immunology
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Monocytes / drug effects
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Monocytes / immunology
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Monocytes / metabolism
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Paecilomyces / chemistry*
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Pinocytosis / drug effects
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Polysaccharides / isolation & purification*
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Polysaccharides / pharmacology*
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Rats
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Immunologic Factors
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Polysaccharides
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Tumor Necrosis Factor-alpha
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L-Lactate Dehydrogenase
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Acid Phosphatase