Recent development of computed tomography and three-dimensional visualization techniques has enabled the non-destructive inspection of the endocast morphology of fossil neurocranium, the basic material for paleoneurological study. A virtual cranial endocast was reconstructed based on the first skull of the oldest giant panda, Ailuropoda microta, discovered recently and dated at more than 2 Myr (million years) ago. It was compared with that of the extant giant panda (A. melanoleuca) and that of the polar bear (Ursus maritimus), as well as CT slices of the late Pleistocene A. baconi. The overall endocast morphology of A. microta is more similar to that of A. baconi and A. melanoleuca than to that of U. maritimus. The absolute endocast size is the smallest in A. microta, largest in A. baconi, and intermediate in A. melanoleuca. However, the proportion of cerebral volume to total endocast size is very close to each other between the oldest and extant giant panda, as well as the sulcal length per unit area of cerebral endocast surface.