Objective: To investigate whether adiponectin and leptin levels are associated with bone mineral density (BMD) in 232 men (20~80 years old).
Methods: Serum adiponectin and leptin levels were determined by enzyme-linked immunosorbentassay (ELISA). BMD at various sites was determined using dual energy x-ray absorptiometry (DXA).
Results: Adiponectin was negatively correlated with body fat, while leptin had a positively correlation. Significant negative correlations between adiponectin and BMD were found, which remained significant after adjustment of age and body fat. In the multiple linear stepwise regression analysis, adiponectin but not leptin, was independent predictor of BMD.
Conclusion: Adiponectin was an independent predictor of BMD in Chinese men. Adiponectin may exert a negative effect on bone mass.