A new sesquiterpenoid hydroquinone from the marine sponge Dysidea arenaria

Molecules. 2008 Jun 6;13(6):1275-81. doi: 10.3390/molecules13061275.

Abstract

Detailed chemical investigation of the South China sponge Dysidea arenaria resulted in the isolation of a new sesquiterpenoid hydroquinone, 19-hydroxypolyfibrospongol B (1), along with five known compounds: polyfibrospongol B (2), isosemnonorthoquinone (3), ilimaquinone (4), smenospongine (5) and smenotronic acid (6). The structures were determined by extensive spectroscopic analysis. The in vitro anti- HIV activity on HIV-1 RT was evaluated. Compounds 3 -6 displayed moderate inhibitory activity, with IC(50)values of 239.7, 16.4, 176.1, and 130.4 microM, respectively, while 1 and 2 were found to be inactive against the same biological target.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry
  • Anti-HIV Agents / isolation & purification*
  • Anti-HIV Agents / pharmacology
  • China
  • Drug Evaluation, Preclinical
  • Dysidea / chemistry*
  • Hydroquinones / chemistry
  • Hydroquinones / isolation & purification*
  • Hydroquinones / pharmacology*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Reverse Transcriptase Inhibitors / chemistry
  • Reverse Transcriptase Inhibitors / pharmacology
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Spectrum Analysis

Substances

  • Anti-HIV Agents
  • Hydroquinones
  • Reverse Transcriptase Inhibitors
  • Sesquiterpenes
  • hydroquinone