Abstract
Retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) are cytosolic RNA helicases that sense viral RNA and trigger signaling pathways that induce the production of type I interferons (IFNs) and proinflammatory cytokines. RLRs recognize distinct and overlapping sets of viruses, but the mechanisms that dictate this specificity were unknown. A new study now provides evidence for size-based discrimination of double-stranded RNA (dsRNA) by RLRs and suggests how host cells recognize a variety of RNA viruses.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Animals
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Cell Line
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DEAD Box Protein 58
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DEAD-box RNA Helicases / genetics
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DEAD-box RNA Helicases / metabolism*
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Interferon-Induced Helicase, IFIH1
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Mice
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RNA, Double-Stranded / genetics
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RNA, Double-Stranded / metabolism*
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RNA, Viral / genetics
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RNA, Viral / metabolism*
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Vesicular Stomatitis / genetics
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Vesicular Stomatitis / metabolism*
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Vesiculovirus / genetics
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Vesiculovirus / metabolism*
Substances
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RNA, Double-Stranded
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RNA, Viral
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Ddx58 protein, mouse
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Ifih1 protein, mouse
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DEAD Box Protein 58
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DEAD-box RNA Helicases
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Interferon-Induced Helicase, IFIH1