Abstract
The aim of this study was to assess the dopamine function of the temporal cortex in major depressive disorder using [(123)I]epidepride to image D(2/3) receptor binding sites. Ten major depressives and 10 healthy controls were selected from a general population sample for single-photon emission computed tomography imaging. Among the major depressives there was a strong bilateral correlation between the scores on the 21-item Hamilton Depression Rating Scale and D(2/3) receptor binding. Dopaminergic abnormalities may be present in the temporal cortices of major depressives.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Benzamides*
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Depressive Disorder, Major / diagnostic imaging*
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Depressive Disorder, Major / physiopathology*
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Depressive Disorder, Major / psychology
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Dominance, Cerebral / physiology
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Female
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Humans
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Iodine Radioisotopes
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Male
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Middle Aged
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Personality Inventory
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Pyrrolidines*
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Receptors, Dopamine D2 / physiology*
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Receptors, Dopamine D3 / physiology*
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Statistics as Topic
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Temporal Lobe / diagnostic imaging*
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Temporal Lobe / physiopathology*
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Tomography, Emission-Computed, Single-Photon*
Substances
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Benzamides
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Iodine Radioisotopes
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Pyrrolidines
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Receptors, Dopamine D2
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Receptors, Dopamine D3
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epidepride