Abstract
KRN7000 is an important ligand identified for CD1d protein of APC, and KRN7000/CD1d complex can stimulate NKT cells to release Th1 and Th2 cytokines. In an effort to understand the structure-activity relationships, we have carried out the synthesis of a complete set of the eight KRN7000 stereoisomers, and their biological activities have been examined.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic / chemical synthesis
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Adjuvants, Immunologic / chemistry
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Antigens, CD1 / chemistry*
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Antigens, CD1 / metabolism
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Antigens, CD1d
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Chemistry, Pharmaceutical / methods
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Drug Design
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Galactosylceramides / chemical synthesis*
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Galactosylceramides / chemistry*
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Humans
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Killer Cells, Natural / immunology*
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Killer Cells, Natural / metabolism
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Ligands
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Models, Chemical
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Protein Binding
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Stereoisomerism
Substances
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Adjuvants, Immunologic
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Antigens, CD1
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Antigens, CD1d
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CD1D protein, human
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Galactosylceramides
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Ligands
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alpha-galactosylceramide
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KRN 7000