Abstract
Noncoding RNAs are emerging as central players in gene expression regulation through the targeting of a plethora of mRNAs. Several recent papers report on the regulation of the epithelial phenotype by the miR-200 (200 family of miRNAs) family and a natural antisense transcript, both acting on the E-cadherin repressors zinc-finger E-box-binding homeobox factors ZEB1 and ZEB2. These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Embryonic Development
-
Epithelial Cells*
-
Gene Expression Regulation
-
Homeodomain Proteins / genetics
-
Humans
-
Mesenchymal Stem Cells*
-
MicroRNAs / physiology
-
Neoplasms / genetics
-
Neoplasms / pathology
-
RNA, Antisense / physiology*
-
Repressor Proteins / genetics
-
Transcription Factors / genetics
-
Zinc Finger E-box Binding Homeobox 2
-
Zinc Finger E-box-Binding Homeobox 1
Substances
-
Homeodomain Proteins
-
MicroRNAs
-
RNA, Antisense
-
Repressor Proteins
-
Transcription Factors
-
ZEB1 protein, human
-
ZEB2 protein, human
-
Zinc Finger E-box Binding Homeobox 2
-
Zinc Finger E-box-Binding Homeobox 1