Objective: To assess the biocompatibility of different biopolymers with cochlea implant.
Materials and methods: Six bioabsorbable polymers and biostable silicone were used for testing histologic reactions in the cochlea of the rat. The samples were prepared from three 50/50 poly(DL-lactide-co-glycolide) PDLLGA having different inherent viscosity (IV) values and 75/25 poly(DL-lactide-co-epsilon-caprolactone) P(DLLA/CL), poly-epsilon-caprolactone PCL, silicone, and chitosan by extruding the biomaterial as a rod using melt molding (for 50/50 PDLLGAs and 75/25 P(DLLA/CL) and PCL), blending (for silicone), and solving (for chitosan). The rods were cut into samples of diameter of 0.5 mm and length of 2 mm. All the samples were packed and sterilized by gamma irradiation (18 kGy, less than 42 degrees C). Twenty-two male and female Sprague-Dawley rats were used in the study. Four months after the implantation, the animals were killed for histologic observation.
Results: Chitosan does not degrade in the cochlea 4 months after implantation and, therefore, stimulates very weak inflammatory reaction. The 50/50 PDLLGA (IV, 0.83 dL/g) degrades in the cochlea 4 months after implantation and does not stimulate inflammatory reaction. The 50/50 PDLLGA (IV, 0.41 dL/g; IV, 0.37 dL/g), 75/25 P(DLLA/CL), PCL, and silicone might induce strong inflammatory reaction in the cochlea.
Conclusion: Different degradation property of biomaterials in the cochlea indicates diverse drug releasing time in a controlled way. Chitosan is suitable for long-lasting drug delivery, whereas 50/50 PDLLGA (IV, 0.83 dL/g) favors quicker releasing. Both chitosan and 50/50 PDLLGA (IV, 0.83 dL/g) are ideal materials for cochlear drug delivery.