Abstract
A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5',5'-pyrophospate bridge (BVDUp(2)dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp(2)dFdC showed a cytotoxicity similar to that of Gemcitabine.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimetabolites, Antineoplastic / chemical synthesis*
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Antimetabolites, Antineoplastic / chemistry
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Antimetabolites, Antineoplastic / pharmacology*
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology
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Bromodeoxyuridine / analogs & derivatives*
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Bromodeoxyuridine / chemical synthesis
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Bromodeoxyuridine / chemistry
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Bromodeoxyuridine / pharmacology
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Cell Line, Tumor
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Deoxycytidine / analogs & derivatives*
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Deoxycytidine / chemical synthesis
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Deoxycytidine / chemistry
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Deoxycytidine / pharmacology
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Drug Screening Assays, Antitumor
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Gemcitabine
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Rats
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Sarcoma, Experimental / drug therapy
Substances
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Antimetabolites, Antineoplastic
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Antiviral Agents
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Deoxycytidine
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brivudine
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Bromodeoxyuridine
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Gemcitabine