Synthesis and antitumor activity of a heterodinucleotide of BVDU and gemcitabine

Nucleosides Nucleotides Nucleic Acids. 2008 May;27(5):460-8. doi: 10.1080/15257770802088787.

Abstract

A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5',5'-pyrophospate bridge (BVDUp(2)dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp(2)dFdC showed a cytotoxicity similar to that of Gemcitabine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimetabolites, Antineoplastic / chemical synthesis*
  • Antimetabolites, Antineoplastic / chemistry
  • Antimetabolites, Antineoplastic / pharmacology*
  • Antiviral Agents / chemical synthesis
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Bromodeoxyuridine / analogs & derivatives*
  • Bromodeoxyuridine / chemical synthesis
  • Bromodeoxyuridine / chemistry
  • Bromodeoxyuridine / pharmacology
  • Cell Line, Tumor
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / chemical synthesis
  • Deoxycytidine / chemistry
  • Deoxycytidine / pharmacology
  • Drug Screening Assays, Antitumor
  • Gemcitabine
  • Rats
  • Sarcoma, Experimental / drug therapy

Substances

  • Antimetabolites, Antineoplastic
  • Antiviral Agents
  • Deoxycytidine
  • brivudine
  • Bromodeoxyuridine
  • Gemcitabine