Effects of mode of oral iron administration on serum ferritin and haemoglobin in infants

Acta Paediatr. 2008 Aug;97(8):1055-60. doi: 10.1111/j.1651-2227.2008.00899.x. Epub 2008 Jun 28.

Abstract

Aim: To investigate effects of iron-fortified foods (FFs) and medicinal iron drops (MD) on iron status in infants.

Methods: Data from one MD and one FF study were compared. Infants were divided into groups depending on the predominant source and amount of dietary iron during 6-9 months of age: MD: Medicinal iron drops (1 mg/kg/day). FF: iron intake >1.3 mg/kg/day, predominantly from FF and no iron supplements. Low iron (LI) group: iron intake <1.3 mg/kg/day and no iron supplements.

Results: Mean iron intake did not differ between MD (n = 30) and FF (n = 35) groups but was lower in the LI (n = 232) group. The FF group had significantly higher mean Hb at 9 months compared to the MD and LI groups (120 vs. 115 g/L and 120 vs. 116 g/L, respectively, p < or = 0.005). The MD group had significantly higher mean SF at 9 months compared to the FF and the LI groups (46 vs. 23 microg/L and 46 vs. 26 microg/L, respectively, p < 0.001).

Conclusions: Our results suggest that, in healthy, term, nonanaemic 6-9-month-old infants, iron given as medicinal iron drops is primarily deposited into iron stores while iron given as iron-fortified foods is primarily utilized for Hb synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Anemia, Iron-Deficiency / drug therapy*
  • Child, Preschool
  • Female
  • Ferritins / blood
  • Ferritins / metabolism*
  • Food, Fortified
  • Hemoglobins / metabolism*
  • Humans
  • Infant
  • Iron / administration & dosage
  • Iron / therapeutic use*
  • Male

Substances

  • Hemoglobins
  • Ferritins
  • Iron