Abstract
Rho GTPases, which control processes such as cell proliferation and cytoskeleton remodeling, are often hyper-expressed in tumors. Several members, such as RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising tool in anticancer therapy.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
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Models, Biological
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Prenylation
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rho GTP-Binding Proteins / antagonists & inhibitors*
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rho GTP-Binding Proteins / metabolism
Substances
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Antineoplastic Agents
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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rho GTP-Binding Proteins