Convenient synthesis of ethyl 4-aryl-6-(trifluoromethyl)-2-oxo-2H-pyran-3-carboxylates and 4-aryl-6-(trifluoromethyl)-2H-pyran-2-ones: novel highly reactive CF3-containing building blocks

Boris I Usachev; Dmitrii L Obydennov; Gerd-Volker Röschenthaler; Vyacheslav Ya Sosnovskikh

doi:10.1021/ol800992z

Convenient synthesis of ethyl 4-aryl-6-(trifluoromethyl)-2-oxo-2H-pyran-3-carboxylates and 4-aryl-6-(trifluoromethyl)-2H-pyran-2-ones: novel highly reactive CF3-containing building blocks

Org Lett. 2008 Jul 3;10(13):2857-9. doi: 10.1021/ol800992z. Epub 2008 Jun 7.

Authors

Boris I Usachev¹, Dmitrii L Obydennov, Gerd-Volker Röschenthaler, Vyacheslav Ya Sosnovskikh

Affiliation

¹ Department of Chemistry, Ural State University, 620083 Ekaterinburg, Russia, and Institute of Inorganic & Physical Chemistry, University of Bremen, 28334 Bremen, Germany. boris.usachev@mail.ru

PMID: 18537252
DOI: 10.1021/ol800992z

Abstract

An expedient synthesis of a series of 2-pyrones, bearing a CF 3 group at the 6-position and aryl group at position 4, from readily available aryl-4,4,4-trifluorobutane-1,3-diones, PCl 5, and sodium diethyl malonate is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carboxylic Acids / chemical synthesis*
Carboxylic Acids / chemistry
Fluorine Compounds / chemical synthesis*
Fluorine Compounds / chemistry
Methylation
Molecular Structure
Oxygen / chemistry*
Pyrans / chemical synthesis*
Pyrans / chemistry

Substances

Carboxylic Acids
Fluorine Compounds
Pyrans
Oxygen