Triterpenoidal saponins from the barks of Zygophyllum fabago L

Chem Pharm Bull (Tokyo). 2008 Jun;56(6):858-60. doi: 10.1248/cpb.56.858.

Abstract

Two new triterpenoid saponins, zygophylosides O (1) and P (2), have been isolated from the barks of Zygophyllum fabago L. Their structures were elucidated as 3beta-[(2-O-sulfo-beta-D-xylopyranosyl)oxy]urs-12-ene-27,28-dioic acid and 3beta-[(2-O-sulfo-beta-D-xylopyranosyl)oxy]urs-12-ene-27,28-dioic acid 28-beta-D-glucopyranoside, respectively, by spectral and chemical evidence. Compound 1 showed weaker Nitric Oxide (NO) inhibitory activity.

MeSH terms

  • Animals
  • Cell Line
  • Hydrolysis
  • Macrophages / metabolism
  • Magnetic Resonance Spectroscopy
  • Mice
  • Molecular Conformation
  • Nitric Oxide / antagonists & inhibitors
  • Nitric Oxide / biosynthesis
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Saponins / isolation & purification*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Tetrazolium Salts
  • Thiazoles
  • Triterpenes / isolation & purification*
  • Zygophyllum / chemistry*

Substances

  • Plant Extracts
  • Saponins
  • Tetrazolium Salts
  • Thiazoles
  • Triterpenes
  • zygophyloside O
  • zygophyloside P
  • Nitric Oxide
  • thiazolyl blue