Alpha-glucosidase inhibitor from Chinese aloes

Nilubon Jong-Anurakkun; Megh Raj Bhandari; Gao Hong; Jun Kawabata

doi:10.1016/j.fitote.2008.02.010

Alpha-glucosidase inhibitor from Chinese aloes

Fitoterapia. 2008 Sep;79(6):456-7. doi: 10.1016/j.fitote.2008.02.010. Epub 2008 May 27.

Authors

Nilubon Jong-Anurakkun¹, Megh Raj Bhandari, Gao Hong, Jun Kawabata

Affiliation

¹ Laboratory of Food Biochemistry, Division of Applied Bioscience,Graduate School of Agriculture, Hokkaido University, Sapporo 060-8589, Japan. j_nilubon@hotmail.com

PMID: 18508205
DOI: 10.1016/j.fitote.2008.02.010

Abstract

Activity-guided fractionation of the methanol extract of Chinese aloes led to the isolation of aloeresin A, which demonstrated significant dose dependent alpha-glucosidase inhibitory activities, with IC(50) values of 11.94 and 2.16 mM, against rat intestinal sucrase and maltase, respectively.

MeSH terms

Aloe / chemistry*
Animals
Blood Glucose / drug effects
Chromones / chemistry
Chromones / isolation & purification
Chromones / pharmacology*
Diabetes Mellitus / drug therapy
Drugs, Chinese Herbal
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Glucosides / chemistry
Glucosides / isolation & purification
Glucosides / pharmacology*
Glycoside Hydrolase Inhibitors*
Inhibitory Concentration 50
Molecular Structure
Phytotherapy
Plant Leaves
Rats

Substances

Blood Glucose
Chromones
Drugs, Chinese Herbal
Enzyme Inhibitors
Glucosides
Glycoside Hydrolase Inhibitors
aloeresin A