Catalytic enantioselective Reformatsky reaction with ketones

Chem Commun (Camb). 2008 Jun 14:(22):2571-3. doi: 10.1039/b801749b. Epub 2008 Apr 1.

Abstract

Chiral tertiary alcohols were obtained with good yields and enantioselectivities via a catalytic Reformatsky reaction with ketones, including the challenging diaryl ketones, using chiral BINOL derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemical synthesis*
  • Alcohols / chemistry
  • Catalysis
  • Iodoacetates / chemistry
  • Ketones / chemistry*
  • Models, Chemical
  • Molecular Structure
  • Naphthols / chemistry
  • Organometallic Compounds / chemistry
  • Oxygen / chemistry
  • Stereoisomerism

Substances

  • Alcohols
  • BINOL, naphthol
  • Iodoacetates
  • Ketones
  • Naphthols
  • Organometallic Compounds
  • dimethylzinc
  • Oxygen