Characterization of the carbapenem-hydrolyzing oxacillinase oxa-58 in an Acinetobacter genospecies 3 clinical isolate

Antimicrob Agents Chemother. 2008 Aug;52(8):2955-8. doi: 10.1128/AAC.00072-08. Epub 2008 May 27.

Abstract

Based on imipenem resistance in an Acinetobacter genospecies 3 clinical isolate, we were able to identify, for the first time in this genomic species, a plasmid-encoded bla(OXA-58) gene that was 100% homologous to the same gene in Acinetobacter baumannii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter / genetics
  • Acinetobacter / metabolism
  • Acinetobacter Infections / microbiology
  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Base Sequence
  • Carbapenems / metabolism
  • Carbapenems / pharmacology*
  • Humans
  • Imipenem / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Plasmids / genetics
  • Sequence Analysis, DNA
  • beta-Lactamases / genetics
  • beta-Lactamases / metabolism*

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Carbapenems
  • Imipenem
  • beta-Lactamases
  • beta-lactamase OXA-58, Acinetobacter junii

Associated data

  • GENBANK/EU642594