Autologous fat grafting, referred to as lipofilling was described first by Neuber in 1893. It has been gaining great popularity recently due in particular to the intensive development of liposuction and the anatomical availability of various subcutaneous adipose tissue depots in the human body. In the present study we present our experience in autulogous fat grafting for the reconstruction of soft tissue defects as well as for face rejuvenation and body contouring. Between May 2003 and May 2005 we performed lipofilling surgery in 13 patients at the Department of Plastic and Craniofacial Surgery in St. George University Hospital, Plovdiv. The grafts were harvested by lipoaspiration and, after subsequent treatment, re-injected. Our results are still preliminary because of the short terms of patients' follow-up. The most common complications at the recipient site were partial resorption of the graft and cyst formation, and at the donor site--hematoma.