The authors analyze the impact chronic skin ulcers have on Life Quality Related to Health in relation with morphological and clinical variables on the evolution of ulcers treated with SureSkin II by means of the Spanish version of the generic health self-administered questionnaire SF-72 Health Survey (SF-12v2). The authors carried out an observational study based on a series of multi-centric, prospective and open clinical cases. The length of application of this dressing was up to 20 applications or until the ulcer under treatment was cured. 593 patients having an average age of 73 years were included in this study. The authors observed total cicatrisation of the lesion in 64% of the cases. The results showed clear, significant differences (p < 0.001) before and after treatment with the dressing under study for the 8 dimensions which the questionnaire SF-12v2 measures on an ordinal scale from 0 to 100; the average measurements of the dimensions at the time of the final visit were greater than those obtained on the first visit.