Abstract
Given the prevalence of the indole nucleus in biologically active compounds, the direct C3-functionalization of 2,3-disubstituted indoles represents an important problem. Described is a general, high-yielding method for the palladium-catalyzed beta-allylation of carba- and heterocycle fused indoles, including complex natural product substrates.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Allyl Compounds / chemistry
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Carbazoles / chemistry
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Carbolines / chemistry
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Catalysis
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Combinatorial Chemistry Techniques
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Indoles / chemical synthesis*
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Indoles / chemistry*
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Molecular Structure
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Palladium / chemistry*
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Stereoisomerism
Substances
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Allyl Compounds
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Carbazoles
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Carbolines
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Indoles
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Palladium