The application of a new kind of technique involving solid-phase extraction coupled with thermal desorption (SPE-TD) to the qualitative analysis of water used in pharmaceutical products was evaluated. Comparative analyses performed by the purge and trap (PT) technique were also conducted. The application of this SPE-TD technique resulted in the isolation of a large number of compounds from the water sample. The SPE-TD technique is applied to less volatile compounds, whereas the PT technique is used for more volatile and nonpolar ones. These two techniques should be applied in order to achieve complete identification and quantitative determination. Additionally, an attempt to identify organic compounds in pharmaceutical products was also conducted. The compounds present in such products include aldehydes, ketones, hydrocarbons, alcohols, esters. The influence of storage on the quality of water was also investigated. For samples characterized by a longer storage time, qualitatively richer chromatograms were obtained, which confirmed that components were released from the packaging (especially polyethylene) which entered the stored product.