Peripheral neuropathy is a general term for peripheral nerve disease. The impairment of peripheral nerve is a very frequent situation with a limited clinical expression, but with several subjacent etiologies. Therefore in clinical practice more complicated than identify a neuropathy is the work-up of its etiological study. The clinical investigation and electrophysiologic study are fundamental in the investigation study of a neuropathy. The authors present a schematic revision work of the principals aspects of neuropathy clinical and study.