[Gel-emulsion systems. II. Stability]

Acta Pharm Hung. 2008;78(1):23-30.
[Article in Hungarian]

Abstract

Viscosity, elastic character of gel emulsions containing polymeric emulsifiers and change of droplet size distribution under storage were studied. The quantitative change of free (non-bound) water and immobilized one in microgel form, and that of the evaporation rate under storage were examined. The phenomena were divided into two groups: change of i) macrostructure, and ii) microstructure. It was determined that macrostructure (e.g. average droplet size) was stable, it did not change during the 3 month storage period. On the other hand, the microstructure (e.g. viscosity, elastic character, solvation of polymer chains, immobilized water in microgel, rate of water evaporation) were characteristically changed during storage. These processes could be related to the sustained hydration of polymer chains.

Publication types

  • English Abstract

MeSH terms

  • Drug Stability
  • Emulsions / chemistry*
  • Gels / chemistry*
  • Water

Substances

  • Emulsions
  • Gels
  • Water