Resisting immune exhaustion in HIV-1 infection

PLoS Med. 2008 May 6;5(5):e103. doi: 10.1371/journal.pmed.0050103.

Abstract

Sarah Rowland-Jones and Thushan de Silva discuss a new study describing the fate of cytotoxic T lymphocytes responding to HIV-1 from very early through to chronic infection.

Publication types

  • Comment

MeSH terms

  • Animals
  • Anti-Retroviral Agents / therapeutic use
  • Antigens, Viral / chemistry
  • Disease Progression
  • Epitopes / chemistry
  • HIV Infections / immunology*
  • HIV-1 / metabolism*
  • Humans
  • Immune System*
  • Phenotype
  • T-Lymphocytes, Cytotoxic / immunology
  • Viral Load
  • Virus Replication

Substances

  • Anti-Retroviral Agents
  • Antigens, Viral
  • Epitopes