Total synthesis of (-)-dysithiazolamide

Ana Ardá; Raquel G Soengas; M Isabel Nieto; Carlos Jiménez; Jaime Rodríguez

doi:10.1021/ol800551g

Total synthesis of (-)-dysithiazolamide

Org Lett. 2008 Jun 5;10(11):2175-8. doi: 10.1021/ol800551g. Epub 2008 May 7.

Authors

Ana Ardá¹, Raquel G Soengas, M Isabel Nieto, Carlos Jiménez, Jaime Rodríguez

Affiliation

¹ Departamento de Química Fundamental, Facultade de Ciencias, Campus da Zapateira, Universidade da Coruña, Coruña, Spain.

PMID: 18459798
DOI: 10.1021/ol800551g

Abstract

The tetrachlorinated natural product (-)-dysithiazolamide was synthesized from l-glutamic acid in a convergent way, confirming the previously proposed (2S,4S,6S,8S) absolute stereochemistry.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Glutamic Acid / chemistry
Stereoisomerism
Thiazoles / chemical synthesis*
Thiazoles / chemistry

Substances

(-)-dysithiazolamide
Thiazoles
Glutamic Acid