Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex

L N Petrova; A V Gabrelian; I V Serkov; S O Bachurin

doi:10.1007/s10517-007-0315-4

Effect of prostaglandins E2 and D2 on presynaptic NMDA receptors in rat cerebral cortex

Bull Exp Biol Med. 2007 Sep;144(3):298-300. doi: 10.1007/s10517-007-0315-4.

Authors

L N Petrova¹, A V Gabrelian, I V Serkov, S O Bachurin

Affiliation

¹ Laboratory for Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chemogolovka. plv@icp.ac.ru

PMID: 18457019
DOI: 10.1007/s10517-007-0315-4

Abstract

We studied the effect of prostaglandins on presynaptic NMDA receptors. Prostaglandin E2 inhibited NMDA-induced (45)Ca2+ uptake by synaptosomes in low concentrations (IC50 approximately 10 microM), but potentiated it in higher concentrations. Prostaglandin D2 increased (45)Ca2+ uptake by synaptosomes during stimulation of NMDA receptors. Our results indicate that prostaglandins D2 and E2 modulate function of presynaptic NMDA receptors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Animals, Newborn
Calcium / metabolism
Cerebral Cortex / cytology
Cerebral Cortex / metabolism*
Dinoprostone / metabolism*
Presynaptic Terminals / metabolism*
Prostaglandin D2 / metabolism*
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate / metabolism*
Synaptosomes / metabolism

Substances

Receptors, N-Methyl-D-Aspartate
Dinoprostone
Prostaglandin D2
Calcium