Activation of natural Hf and Ta in relation to the production of 177Lu

Dmitri G Medvedev; Leonard F Mausner; George A Greene; Albert L Hanson

doi:10.1016/j.apradiso.2008.02.090

Activation of natural Hf and Ta in relation to the production of 177Lu

Appl Radiat Isot. 2008 Oct;66(10):1300-6. doi: 10.1016/j.apradiso.2008.02.090. Epub 2008 Mar 7.

Authors

Dmitri G Medvedev¹, Leonard F Mausner, George A Greene, Albert L Hanson

Affiliation

¹ Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA. dmedvede@bnl.gov

PMID: 18456503
DOI: 10.1016/j.apradiso.2008.02.090

Abstract

The isotope (177)Lu is used in nuclear medicine and biology for in vivo applications as a radioactive label of various targeting agents. To extend the availability of no-carrier added (177)Lu, we investigated the feasibility of its production in a proton accelerator. Tantalum and Hf targets were irradiated and chemically processed to determine the radioisotope yield and cross-sections. The largest cross-sections (approximately 20 mb) were found for the Hf target at 195 MeV; however, the presence of co-produced Lu isotopes may limit the product applications. The results are in good agreement with theoretical data calculated using computer codes MCNPX and ORIGEN2S. Production of relevant medical isotopes such as (167)Tm and (169)Yb from the above targets is discussed as well.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Computer Simulation
Feasibility Studies
Hafnium / chemistry*
Hafnium / radiation effects
Lutetium / chemistry*
Models, Chemical*
Radioisotopes / chemistry*
Tantalum / chemistry*
Tantalum / radiation effects

Substances

Radioisotopes
Lutetium
Tantalum
Hafnium