Abstract
Two new bicyclic hexapeptides, RA-XXIII and RA-XXIV, were isolated from the roots of Rubia cordifolia L. (Rubiaceae). Their structures were determined by the analysis of their 2D NMR spectra, chemical methods, and X-ray crystallography. The IC50 values of RA-XXIII and RA-XXIV against P-388 leukemia cells were 0.16 and 0.48 microg/ml, respectively.
MeSH terms
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Ammonia / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Bromine / chemistry
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Crystallography, X-Ray
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Magnetic Resonance Spectroscopy
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Methylation
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Peptides, Cyclic / isolation & purification
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Peptides, Cyclic / pharmacology*
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Plant Roots / chemistry
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Rubia / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
Substances
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Antineoplastic Agents, Phytogenic
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Peptides, Cyclic
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RA-XXIII
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RA-XXIV
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Ammonia
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Bromine