Michael adducts--source for biologically potent heterocycles

Chem Pharm Bull (Tokyo). 2008 May;56(5):647-53. doi: 10.1248/cpb.56.647.

Abstract

A new class of pyrimidinetriones, thioxopyrimidinediones, pyrazolidinediones and isoxazolidinediones were prepared from (E)-1,4-diarylbut-2-ene-1,4-diones. All the new compounds synthesized were screened for antimicrobial activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects
  • Fungi / drug effects
  • Heterocyclic Compounds / chemical synthesis*
  • Heterocyclic Compounds / pharmacology*
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Spectrophotometry, Infrared

Substances

  • Anti-Infective Agents
  • Heterocyclic Compounds
  • Indicators and Reagents