Abstract
Recent reports have demonstrated that specific tumor suppressors are important for both maintaining hematopoietic stem cell (HSC) quiescence and preventing leukemia development, suggesting a connection between these two activities. Matsuoka and colleagues (pp. 986-991) have further illustrated this theme by demonstrating that inactivation of the tumor suppressor Fbxw7 leads to HSC depletion by active cell cycling and the initiation of leukemia.
MeSH terms
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Animals
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Apoptosis
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / physiology*
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Cell Transformation, Neoplastic*
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F-Box Proteins / genetics
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F-Box Proteins / physiology*
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F-Box-WD Repeat-Containing Protein 7
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Gene Deletion
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Hematopoietic Stem Cells / metabolism
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Humans
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Leukemia / genetics
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Leukemia / pathology
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Leukemia / physiopathology
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Models, Biological
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Mutation
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Tumor Suppressor Protein p53 / metabolism
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Ubiquitin-Protein Ligases / genetics
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Ubiquitin-Protein Ligases / physiology*
Substances
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Cell Cycle Proteins
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F-Box Proteins
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F-Box-WD Repeat-Containing Protein 7
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FBXW7 protein, human
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Tumor Suppressor Protein p53
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Ubiquitin-Protein Ligases