Self-renewal versus transformation: Fbxw7 deletion leads to stem cell activation and leukemogenesis

Genes Dev. 2008 May 1;22(9):1107-9. doi: 10.1101/gad.1670708.

Abstract

Recent reports have demonstrated that specific tumor suppressors are important for both maintaining hematopoietic stem cell (HSC) quiescence and preventing leukemia development, suggesting a connection between these two activities. Matsuoka and colleagues (pp. 986-991) have further illustrated this theme by demonstrating that inactivation of the tumor suppressor Fbxw7 leads to HSC depletion by active cell cycling and the initiation of leukemia.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / physiology*
  • Cell Transformation, Neoplastic*
  • F-Box Proteins / genetics
  • F-Box Proteins / physiology*
  • F-Box-WD Repeat-Containing Protein 7
  • Gene Deletion
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Leukemia / genetics
  • Leukemia / pathology
  • Leukemia / physiopathology
  • Models, Biological
  • Mutation
  • Tumor Suppressor Protein p53 / metabolism
  • Ubiquitin-Protein Ligases / genetics
  • Ubiquitin-Protein Ligases / physiology*

Substances

  • Cell Cycle Proteins
  • F-Box Proteins
  • F-Box-WD Repeat-Containing Protein 7
  • FBXW7 protein, human
  • Tumor Suppressor Protein p53
  • Ubiquitin-Protein Ligases