Abstract
Silica sulfuric acid catalyzes efficiently the reaction of sulfonamides with both carboxylic acid anhydrides and chlorides under solvent-free and heterogeneous conditions. All the reactions were done at room temperature and the N-acylsulfonamides were obtained with high yields and purity via an easy work-up procedure. This method is attractive and is in a close agreement with green chemistry. These compounds were also investigated for antibacterial activity, including Gram-positive cocci and Gram-negative bacilli, and carbonic anhydrase II inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Carbonic Anhydrase II / antagonists & inhibitors*
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Carbonic Anhydrase Inhibitors / chemical synthesis*
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Carbonic Anhydrase Inhibitors / chemistry
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Carbonic Anhydrase Inhibitors / pharmacology*
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Catalysis
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Gram-Negative Bacteria / drug effects
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Gram-Positive Cocci / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Silicon Dioxide / chemistry
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Stereoisomerism
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis*
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Sulfonamides / chemistry
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Sulfonamides / pharmacology*
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Sulfuric Acids / chemistry
Substances
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Anti-Bacterial Agents
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Carbonic Anhydrase Inhibitors
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Sulfonamides
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Sulfuric Acids
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Silicon Dioxide
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Carbonic Anhydrase II