Abstract
An outbreak of canine parvovirus type 2c (CPV-2c) infection in vaccinated adult dogs is reported. The disease occurred in a breeding kennel in Italy and affected 11 dogs aged between 6 months and 2.5 years, that had been repeatedly administered vaccines containing a type 2 (old type) CPV strain. CPV infection was demonstrated in all diseased dogs by an immunochromatographic test. A CPV strain was isolated from the intestinal content of a 20-month-old pregnant Bernese mountain bitch that underwent a fatal outcome. The strain was characterised as CPV-2c by means of real-time PCR assays using minor groove binder probes. The present report provides further concerns about the real efficacy of type 2-based vaccines against the antigenic variants of CPV and stresses the need for developing new vaccines prepared with the variants currently circulating in the dog population.
MeSH terms
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Animals
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Antibodies, Viral / blood
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Cell Line
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Disease Outbreaks*
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Dog Diseases / epidemiology
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Dog Diseases / immunology
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Dog Diseases / prevention & control*
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Dog Diseases / virology
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Dogs
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Female
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Gastroenteritis / epidemiology
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Gastroenteritis / immunology
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Gastroenteritis / prevention & control
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Gastroenteritis / veterinary
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Immunization / veterinary
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Male
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Parvoviridae Infections / immunology
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Parvoviridae Infections / prevention & control
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Parvoviridae Infections / veterinary*
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Parvoviridae Infections / virology
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Parvovirus, Canine / immunology*
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Pregnancy
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Pregnancy Complications, Infectious / immunology
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Pregnancy Complications, Infectious / prevention & control
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Pregnancy Complications, Infectious / veterinary
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Pregnancy Complications, Infectious / virology
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Treatment Failure
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Viral Vaccines* / administration & dosage
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Viral Vaccines* / immunology
Substances
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Antibodies, Viral
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Viral Vaccines