Abstract
We describe a girl aged 10.5 years with hyperglycemia, whose mother and maternal father had insulin treated diabetes since adolescence. Using genetic analysis in mother and child, we identified identical new mutation of the HNF-1alpha sequence. Treatment with small doses of sulphonylurea was initiated and that therapy gave good results.
MeSH terms
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Child
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / genetics*
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Female
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Hepatocyte Nuclear Factor 1-alpha / genetics*
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Humans
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Hyperglycemia / diagnosis
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Hyperglycemia / genetics
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Hypoglycemic Agents / therapeutic use*
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Insulin / therapeutic use
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Male
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Mutation*
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Pregnancy
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Pregnancy Complications / drug therapy
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Sulfonylurea Compounds / therapeutic use*
Substances
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HNF1A protein, human
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Hepatocyte Nuclear Factor 1-alpha
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Hypoglycemic Agents
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Insulin
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Sulfonylurea Compounds