Animal models of retroviral encephalopathies: feline model

Michael Podell; Wayne R Buck; Kathleen A Hayes; Mikhail A Gavrilin; Lawrence E Mathes

doi:10.1002/0471142301.ns0909s17

Animal models of retroviral encephalopathies: feline model

Curr Protoc Neurosci. 2002 Feb:Chapter 9:Unit 9.9. doi: 10.1002/0471142301.ns0909s17.

Authors

Michael Podell¹, Wayne R Buck, Kathleen A Hayes, Mikhail A Gavrilin, Lawrence E Mathes

Affiliation

¹ The Ohio State University, Columbus, Ohio, USA.

PMID: 18428574
DOI: 10.1002/0471142301.ns0909s17

Abstract

Human immunodeficiency virus infection in children and adults results in a progressive neurodegenerative disease consistent with a predominant subcortical mediated dementia. Techniques for developing a feline model of the early stages of lentiviral-associated neurodegeneration are presented. The behavioral, neurophysiologic, immunologic, virologic, and neuropathologic aspects of this model are also described.

Publication types

Review

MeSH terms

Animals
Cats / immunology
Cats / virology*
Disease Models, Animal*
Encephalitis, Viral* / immunology
Encephalitis, Viral* / pathology
Encephalitis, Viral* / physiopathology
Encephalitis, Viral* / virology
Feline Acquired Immunodeficiency Syndrome / immunology
Feline Acquired Immunodeficiency Syndrome / pathology
Feline Acquired Immunodeficiency Syndrome / physiopathology
Feline Acquired Immunodeficiency Syndrome / virology*
Humans
Immunodeficiency Virus, Feline / growth & development
Immunodeficiency Virus, Feline / isolation & purification
Immunodeficiency Virus, Feline / pathogenicity*