Abstract
Micronuclear and antitumor activities of two newly synthesized iodides of pyrazolo[1,5a]pyrimidines were investigated using mice model. It has been shown that both compounds are slightly toxic and have no antitumor activity in mice with Ehrlich's ascites carcinoma. Only one of them has weak micronuclear activity. Both compounds increase substantially micronuclear as well as antitumor activities of cyclophosphamide.
MeSH terms
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Animals
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Antineoplastic Agents, Alkylating / therapeutic use
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Carcinoma, Ehrlich Tumor / drug therapy*
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Cyclophosphamide / therapeutic use
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Drug Synergism
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Injections, Intraperitoneal
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Mice
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Micronucleus Tests
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Pyrazoles / administration & dosage
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Pyrazoles / chemistry
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Pyrazoles / therapeutic use*
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Pyrazoles / toxicity*
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Pyrimidines / administration & dosage
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Pyrimidines / chemistry
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Pyrimidines / therapeutic use*
Substances
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Antineoplastic Agents, Alkylating
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Pyrazoles
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Pyrimidines
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Cyclophosphamide
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pyrimidine