Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment

Elena Gaggelli; Zbigniew Grzonka; Henryk Kozłowski; Caterina Migliorini; Elena Molteni; Daniela Valensin; Gianni Valensin

doi:10.1039/b713453c

Structural features of the Cu(II) complex with the rat Abeta(1-28) fragment

Chem Commun (Camb). 2008 Jan 21:(3):341-3. doi: 10.1039/b713453c.

Authors

Elena Gaggelli¹, Zbigniew Grzonka, Henryk Kozłowski, Caterina Migliorini, Elena Molteni, Daniela Valensin, Gianni Valensin

Affiliation

¹ Department of Chemistry, University of Siena, via Aldo Moro, 53100 Siena, Italy.

PMID: 18399201
DOI: 10.1039/b713453c

Abstract

The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Amyloid beta-Peptides / chemistry*
Animals
Binding Sites
Copper / chemistry*
Hydrogen-Ion Concentration
Models, Molecular
Molecular Sequence Data
Peptide Fragments / chemistry*
Protein Structure, Secondary
Rats

Substances

Amyloid beta-Peptides
Peptide Fragments
amyloid beta-protein (1-28)
Copper