Cancer: inappropriate expression of stem cell programs?

Cell Stem Cell. 2008 Apr 10;2(4):297-9. doi: 10.1016/j.stem.2008.03.014.

Abstract

Cancer stem cells (CSCs) are a subpopulation of cancer cells that possess characteristics, including self-renewal, associated with normal stem cells. In this issue of Cell Stem Cell, Wong et al. (2008) define a core embryonic stem cell (ESC)-like gene expression program that may be important for CSC function in multiple epithelial cancers.

Publication types

  • Comment
  • Editorial

MeSH terms

  • Adult Stem Cells / cytology
  • Adult Stem Cells / physiology*
  • Animals
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism*
  • Cell Transformation, Neoplastic
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / physiology*
  • Epithelium / pathology*
  • Humans
  • Neoplasms, Experimental / genetics
  • Neoplasms, Experimental / metabolism
  • Neoplasms, Experimental / pathology*
  • Neoplastic Stem Cells / pathology*
  • Transcription, Genetic*

Substances

  • Biomarkers, Tumor